Separating the good and evil of cardiac growth by CIB1 and calcineurin.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 20816084.
- Also identified by DOI 10.1016/j.cmet.2010.08.007 and PMC identifier 3005713.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
Ca(2+)-calcineurin-NFAT signaling plays a major role in promoting pathological cardiac hypertrophy. Heineke et al. (2010) show that CIB1 strongly enhances calcineurin activation and cardiac hypertrophy upon pathological stress, likely by functioning as a scaffold protein that exposes calcineurin to the L-Type Ca(2+) channel and the sarcolemma.