A new role for cyclic phosphatidic acid as a PPARgamma antagonist.
basic_science · Level V
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- Record sourced from PubMed, PMID 20816085.
- Also identified by DOI 10.1016/j.cmet.2010.08.010.
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Abstract
A recent study in Molecular Cell (Tsukahara et al., 2010) identifies cyclic phosphatidic acid (CPA) as a naturally occurring PPARgamma antagonist that can be generated from lysophospholipids by signal-dependent activation of phospholipase D2. This endogenous CPA regulates PPARgamma functions required for adipogenesis, glucose homeostasis, and vascular wall biology.