Effects of thyroid hormone on A1C and glycated albumin levels in nondiabetic subjects with overt hypothyroidism.
prospective_cohort · Level II
Where this comes from
- Record sourced from PubMed, PMID 20823345.
- Also identified by DOI 10.2337/dc10-0988 and PMC identifier 2992186.
- Licence recorded as CC BY-NC-ND.
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Abstract
We aimed to determine the effects of thyroid hormone on A1C and glycated albumin (GA) in nondiabetic patients with overt hypothyroidism. A1C levels were measured in 45 nondiabetic patients with overt hypothyroidism and 180 euthyroid control subjects. A1C, GA, fasting blood glucose (FBG), 1,5-anhydroglucitol, and erythrocyte indexes were determined in 30 nondiabetic patients with overt hypothyroidism before and after thyroid hormone replacement. A1C levels were higher in patients with hypothyroidism compared with control subjects. A1C levels were decreased by thyroid hormone replacement. Thyroid hormone replacement increased serum erythropoietin, reticulocyte count, and mean corpuscular hemoglobin (MCH). The change in A1C level was significantly correlated with the change in reticulocyte count or MCH. Thyroid hormone replacement decreased serum levels of albumin and GA. However, FBG and 1,5-anhydroglucitol levels were not altered. Levels of A1C and GA are spuriously high in nondiabetic patients with overt hypothyroidism.
Medical subject headings
- Glycated Hemoglobin
- Hypothyroidism
- Thyroid Hormones