Investigation of the potential of polymer therapeutics in corneal re-epithelialisation.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 20829315.
- Also identified by DOI 10.1136/bjo.2009.177295.
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Abstract
In this study, the first use of a bioresponsive polymer therapeutic agent in the promotion of corneal re-epithelialisation after injury in an ex vivo whole-eye organ culture model was described. A polymer-protein conjugate consisting of dextrin and recombinant human epidermal growth factor was synthesised and applied as a single dose to a 2 mm ex vivo corneal ulcer, in culture. Enhanced wound healing was observed in response to dextrin-recombinant human epidermal growth factor, when exposed to α-amylase, compared with controls. This highlights the potential for polymer therapeutics to provide a platform for bioresponsive drug/protein delivery in the field of ophthalmology.
Medical subject headings
- Cornea
- Dextrins
- Organ Culture Techniques
- Polymers
- Regeneration
- Wound Healing