PARP around the clock.
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 20850006.
- Also identified by DOI 10.1016/j.cell.2010.08.037 and PMC identifier 3694762.
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Abstract
Cells possess internal ∼24 hr or circadian clocks that synchronize physiological processes with daily cycles of light and nutrient availability. In this issue, Asher et al. (2010) find that PARP-1 (poly(ADP-ribose) polymerase 1) modifies components of the clock machinery in response to feeding, providing a mechanism for how metabolic rhythms coordinate with circadian rhythms.