PAPP-A: a new anti-aging target?
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 20854420.
- Also identified by DOI 10.1111/j.1474-9726.2010.00630.x and PMC identifier 3047409.
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Abstract
This article focuses on the role of PAPP-A in mammalian aging. It introduces PAPP-A and a little of its history, briefly discusses the function of PAPP-A in the insulin-like growth factor (IGF) system and the regulators of PAPP-A expression, and then reviews data concerning PAPP-A in aging and age-related diseases especially in regard to the PAPP-A knockout (KO) mouse. The PAPP-A KO mouse is a valuable new model to test hypotheses concerning the control of the tissue availability of IGF, independent from systemic levels, on healthspan as well as lifespan.
Medical subject headings
- Aging
- Pregnancy-Associated Plasma Protein-A