SpotXplore: a Cytoscape plugin for visual exploration of hotspot expression in gene regulatory networks.

Westenberg, Michel A; Roerdink, Jos B T M; Kuipers, Oscar P; van Hijum, Sacha A F T · Bioinformatics · 2010

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Abstract

SpotXplore is a plugin for Cytoscape for extraction and visualization of differentially expressed subnetworks (hotspots) from gene networks. The hotspot-based visualization approach enables interactive exploration of regulatory interactions in differentially expressed gene sets, and it allows a researcher to explore gene expression in direct relation to the affected cellular gene network. The hotspots provide a view beyond the commonly used metabolic pathways and gene ontologies. http://www.win.tue.nl/∼mwestenb/spotxplore/.

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