Upper urinary tract infections are associated with RANTES promoter polymorphism.

Centi, Sonia; Negrisolo, Susanna; Stefanic, Alejandra; Benetti, Elisa; Cassar, Walburga; Da Dalt, Liviana; Rigamonti, Waifro; Zucchetta, Pietro et al. · J Pediatr · 2010

case_control · Level III

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Abstract

We evaluated the association between MCP-1, CCR2, RANTES, and CCR5 gene polymorphisms and upper urinary tract infection in 273 children recruited in Northeast Italy. Statistical analysis of RANTES-403 G>A genotype frequencies showed that children carrying the RANTES-403 G allele are at higher risk for urinary tract infection, irrespective of vesicoureteral reflux.

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