Systematic review and meta-analysis of preoperative antisepsis with chlorhexidine versus povidone-iodine in clean-contaminated surgery.
meta_analysis · Level I
Where this comes from
- Record sourced from PubMed, PMID 20878942.
- Also identified by DOI 10.1002/bjs.7214.
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Abstract
Surgical-site infection increases morbidity, mortality and financial burden. The preferred topical antiseptic agent (chlorhexidine or povidone-iodine) for preoperative skin cleansing is unclear. A meta-analysis of clinical trials was conducted to determine whether preoperative antisepsis with chlorhexidine or povidone-iodine reduced surgical-site infection in clean-contaminated surgery. The systematic review identified six eligible studies, containing 5031 patients. Chlorhexidine reduced postoperative surgical-site infection compared with povidone-iodine (pooled odds ratio 0.68, 95 per cent confidence interval 0.50 to 0.94; P = 0.019) . Chlorhexidine should be used preferentially for preoperative antisepsis in clean-contaminated surgery.
Medical subject headings
- Anti-Infective Agents, Local
- Chlorhexidine
- Povidone-Iodine
- Surgical Wound Infection