How to survive aneuploidy.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 20887888.
- Also identified by DOI 10.1016/j.cell.2010.09.030 and PMC identifier 2955074.
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Abstract
Aneuploidy, or an abnormal number of chromosomes, adversely affects cell growth, but it is also linked with cancer and tumorigenesis. Now, Torres et al. (2010) help to resolve this paradox by demonstrating that aneuploid yeast cells can evolve mutations in the proteasome protein degradation pathway that alleviate imbalances in protein production and increase the cell's proliferative capacities.