The yin and yang of polycomb repression in regenerating muscle.
editorial · Level V
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- Record sourced from PubMed, PMID 20887945.
- Also identified by DOI 10.1016/j.stem.2010.09.005.
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Abstract
Tumor necrosis factor-α (TNF-α) has complex effects on muscle regeneration. In this issue of Cell Stem Cell, Palacios et al. (2010) report that TNF-α-activated p38α kinase controls differentiation of muscle stem cells by promoting polycomb repressive complex 2 (PRC2) silencing of the Pax7 promoter.