A new cohesive team to mediate DNA looping.
review · Level V
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- Record sourced from PubMed, PMID 20887946.
- Also identified by DOI 10.1016/j.stem.2010.09.006.
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Abstract
To control cell-type specific gene expression, transcription factors bound at distant enhancer sites need to come into the vicinity of promoters. In a recent Nature article, Kagey et al. (2010) provide evidence that Mediator and Cohesin protein complexes cooperate in the formation of enhancer-promoter DNA loops.