Metabolic dysfunction in the pathogenesis of pulmonary hypertension.
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- Record sourced from PubMed, PMID 20889122.
- Also identified by DOI 10.1016/j.cmet.2010.09.006.
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Abstract
Pulmonary artery hypertension is characterized by proliferation in the resistance vessels. A recent study in Science Translational Medicine (Sutendra et al., 2010) found that increased fatty acid oxidation and a shift in the glycolysis/glucose oxidation ratio may be central to the pathogenesis of this process, suggesting that these abnormalities comprise novel treatment targets.