The tissue is the issue: personalized medicine for non-small cell lung cancer.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 20926402.
- Also identified by DOI 10.1158/1078-0432.CCR-10-2005.
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Abstract
The development of molecular markers is crucial for improving therapy in advanced non-small cell lung cancer (NSCLC). Here, we review perspectives of biomarker-driven personalized therapy in NSCLC, with particular reference to the detection of EML4-ALK gene rearrangements. Different molecular assays, validation, and clinical application to different types of tissue specimens are discussed.
Medical subject headings
- Carcinoma, Non-Small-Cell Lung
- Lung Neoplasms
- Molecular Targeted Therapy
- Precision Medicine