Efficient hepatitis C virus particle formation requires diacylglycerol acyltransferase-1.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 20935628.
- Also identified by DOI 10.1038/nm.2238 and PMC identifier 3431199.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
Hepatitis C virus (HCV) infection is closely tied to the lipid metabolism of liver cells. Here we identify the triglyceride-synthesizing enzyme diacylglycerol acyltransferase-1 (DGAT1) as a key host factor for HCV infection. DGAT1 interacts with the viral nucleocapsid core and is required for the trafficking of core to lipid droplets. Inhibition of DGAT1 activity or RNAi-mediated knockdown of DGAT1 severely impairs infectious virion production, implicating DGAT1 as a new target for antiviral therapy.
Medical subject headings
- Diacylglycerol O-Acyltransferase
- Hepacivirus
- Virion
- Virus Assembly