Coating optimization of superparamagnetic iron oxide nanoparticles for high T2 relaxivity.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 20939602.
- Also identified by DOI 10.1021/nl102623x and PMC identifier 3170660.
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Abstract
We describe a new method for coating superparamagnetic iron oxide nanoparticles (SPIOs) and demonstrate that, by fine-tuning the core size and PEG coating of SPIOs, the T2 relaxivity per particle can be increased by >200-fold. With 14 nm core and PEG1000 coating, SPIOs can have T2 relaxivity of 385 s-1 mM-1, which is among the highest per-Fe atom relaxivities. In vivo tumor imaging results demonstrated the potential of the SPIOs for clinical applications.
Medical subject headings
- Coated Materials, Biocompatible
- Dextrans
- Glioblastoma
- Magnetic Resonance Imaging
- Magnetite Nanoparticles
- Nanostructures
- Polyethylene Glycols