Insider influence on ErbB activity.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 20946975.
- Also identified by DOI 10.1016/j.cell.2010.09.042.
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Abstract
The receptor tyrosine kinase ErbB is activated by ligand-induced dimerization, leading to transphosphorylation of the cytoplasmic kinase domains. Bill et al. (2010) now demonstrate that transphosphorylation can be modulated from within the cell by the cytoplasmic protein cytohesin, providing new insights into ErbB-dependent processes during normal development and cancer.