The Myc connection: ES cells and cancer.
basic_science · Level V
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- Record sourced from PubMed, PMID 20946977.
- Also identified by DOI 10.1016/j.cell.2010.09.046.
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Abstract
Gene profiling experiments have revealed similarities between cancer and embryonic stem (ES) cells. Kim et al. (2010) dissect the gene expression signature of ES cells into three functional modules and find that the Myc module, including genes targeted by Myc-interacting proteins, accounts for most of the similarity between ES and cancer cells.