Emerging role of ISG15 in antiviral immunity.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 20946978.
- Also identified by DOI 10.1016/j.cell.2010.09.033 and PMC identifier 2981609.
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Abstract
Cells express a plethora of interferon-stimulated genes (ISGs) in response to viral infection. Among these is ISG15, a ubiquitin-like protein (UBL) that can be covalently attached to both host and viral proteins. Here we review recent advances toward understanding the role and mechanism of ISG15 modification in antiviral defense.
Medical subject headings
- Cytokines
- Ubiquitins
- Virus Diseases
- Viruses