FIH1 (factor inhibiting HIF-1) in the kidney: more than an oxygen sensor?
Level V
Where this comes from
- Record sourced from PubMed, PMID 20948541.
- Also identified by DOI 10.1038/ki.2010.282.
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Abstract
Factor inhibiting HIF-1 (FIH1) inhibits the activity of hypoxia-inducible factor 1 (HIF-1) by preventing HIF-1α from binding to p300/CBP. Schödel et al. demonstrate that, in the kidney, FIH1 is expressed selectively in the distal tubules and podocytes. Although FIH1 functions as a transcriptional repressor of HIF target genes in tubular cells, it does not do so in podocytes. This study suggests that FIH1 may have diverse implications for distal tubular function and podocyte biology.
Medical subject headings
- Kidney Tubules, Distal
- Mixed Function Oxygenases
- Oxygen
- Podocytes
- Repressor Proteins