Ephecting excitatory synapse development.
basic_science · Level V
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- Record sourced from PubMed, PMID 21029857.
- Also identified by DOI 10.1016/j.cell.2010.10.017 and PMC identifier 2976528.
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Abstract
Alterations in synapse number and morphology are associated with devastating psychiatric and neurologic disorders. In this issue of Cell, Margolis et al. (2010) show that the RhoA-guanine exchange factor (GEF) Ephexin5 limits the numbers of excitatory synapses that neurons receive, thus identifying a new mechanism controlling synaptogenesis.