Parathyroid resistance to FGF23 in kidney transplant recipients: back to the past or ahead to the future?
Level V
Where this comes from
- Record sourced from PubMed, PMID 21030971.
- Also identified by DOI 10.1038/ki.2010.283.
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Abstract
Fibroblast growth factor 23 (FGF23) modulates the metabolism of minerals and vitamin D. In chronic kidney disease (CKD), this process is disturbed owing to decreased parathyroid expression of FGF23's receptor complex Klotho-FGF receptor 1. In this issue, Krajisnik and colleagues demonstrate that similar alterations occur in parathyroid glands from kidney transplant recipients in association with a decline in allograft function. Is it possible that these data can be extrapolated to general early-stage CKD patients?
Medical subject headings
- Fibroblast Growth Factors
- Kidney Diseases
- Kidney Transplantation
- Parathyroid Glands