Megarole for microRNA in muscle disease.
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- Record sourced from PubMed, PMID 21035752.
- Also identified by DOI 10.1016/j.cmet.2010.10.007.
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Abstract
Deregulation of microRNAs in dystrophic muscle highlights their importance in muscle homeostasis. A recent study in Cell Metabolism (Cacchiarelli et al., 2010) shows that the presence of functional dystrophin is required for NO-dependent nitrosylation of the HDAC2 repressor and subsequent activation of a group of microRNAs required for muscle function.