IL-1β activation as a response to metabolic disturbances.
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- Record sourced from PubMed, PMID 21035753.
- Also identified by DOI 10.1016/j.cmet.2010.10.002.
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Abstract
IL-1β is a major regulator of islet inflammation in type 2 diabetes. Several factors contribute to the induction of islet-derived IL-1β, including glucose, free fatty acids, and leptin. A recent report in Nature Immunology (Masters et al., 2010) identifies amyloid polypeptide as an additional enhancer of IL-1β production.