Allosteric trumps covalent in the control of glycogen synthesis.
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- Record sourced from PubMed, PMID 21035754.
- Also identified by DOI 10.1016/j.cmet.2010.10.008.
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Abstract
Glycogen metabolism serves as a critical regulator of energy storage and maintenance of blood glucose levels in a physiological range. In this issue of Cell Metabolism, Bouskila et al. (2010) unexpectedly find that skeletal muscle glycogen accumulation is principally controlled by the allosteric activation of glycogen synthase, opening new avenues for investigation.