Association of the CBLB gene with multiple sclerosis: new evidence from a replication study in an Italian population.
case_control · Level III
Where this comes from
- Record sourced from PubMed, PMID 21037273.
- Also identified by DOI 10.1136/jmg.2010.081380.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
The T allele of rs9657904 within the CBLB gene was recently found to be significantly associated with multiple sclerosis (MS) in a genome-wide association study in Sardinia. To replicate this association in an independent population with a different genetic background. The rs9657904 variant was typed in a sample of 1435 cases and 1466 controls from the Italian mainland. It was found that in this sample also, the common allele T of rs9657904 is significantly positively associated (one-tailed p=7.35 × 10(-5)) and with a comparable effect size with MS (OR=1.31, 95% CI 1.14 to 1.52). These data provide further evidence of the association of MS disease with variation within CBLB.
Medical subject headings
- Adaptor Proteins, Signal Transducing
- Multiple Sclerosis
- Proto-Oncogene Proteins c-cbl
- White People