Osteoarthritis: Small studies overestimate the benefit of therapies for OA.

Finckh, Axel; Tramèr, Martin R · Nat Rev Rheumatol · 2010

meta_analysis · Level I

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Abstract

a meta-epidemiological study has revealed that the inclusion of small studies in meta-analyses of osteoarthritis interventions could lead to an overestimation of the benefit of these interventions. Does this mean meta-analyses should be restricted to trials with large sample sizes?

Medical subject headings