Virus-PEDOT nanowires for biosensing.

Arter, Jessica A; Taggart, David K; McIntire, Theresa M; Penner, Reginald M; Weiss, Gregory A · Nano Lett · 2010

basic_science · Level V

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Abstract

The separate fields of conducting polymer-based electrochemical sensors and virus-based molecular recognition offer numerous advantages for biosensing. Grafting M13 bacteriophage into an array of poly (3,4-ethylenedioxythiophene) (PEDOT) nanowires generated hybrids of conducting polymers and viruses. The virus incorporation into the polymeric backbone of PEDOT occurs during electropolymerization via lithographically patterned nanowire electrodeposition. The resultant arrays of virus-PEDOT nanowires enable real-time, reagent-free electrochemical biosensing of analytes in physiologically relevant buffers.

Medical subject headings