Getting to the core of repeat expansions by cell reprogramming.
basic_science · Level V
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- Record sourced from PubMed, PMID 21040891.
- Also identified by DOI 10.1016/j.stem.2010.10.005 and PMC identifier 3008408.
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Abstract
In this issue of Cell Stem Cell, Ku et al. (2010) demonstrate that iPSCS derived from Friedreich's ataxia patients exhibit expansion of the causative (GAA)(n) repeat, consistent with the repeat instability observed during intergenerational transmissions in humans. Furthermore, the epigenetic signature of the disease remains intact in Friedreich's ataxia iPSCs.