Stem cells and osteoporosis therapy.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 21040895.
- Also identified by DOI 10.1016/j.stem.2010.10.004.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
Skeletal remodeling requires recruitment of osteoblast precursors, in the form of MSCs, to the bone surface. In this issue of Cell Stem Cell, Wu et al. (2010) demonstrate that this event is mediated by osteoclastic mobilization of active transforming growth factor β1, which is inhibited by a common antiosteoporosis drug.
Medical subject headings
- Mesenchymal Stem Cells
- Osteoblasts
- Osteoclasts
- Osteoporosis
- Transforming Growth Factor beta1