Heading in a new direction: drug permeability in breast cancer brain metastasis.
other · Level V
Where this comes from
- Record sourced from PubMed, PMID 21045085.
- Also identified by DOI 10.1158/1078-0432.CCR-10-2502.
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Abstract
Systemic therapies for breast cancer brain metastasis are largely unsuccessful. Mouse models of brain metastasis show significant heterogeneity in uptake of paclitaxel and doxorubicin, with average levels more than those seen in normal brain tissue, but significantly less than in metastases to other organs.
Medical subject headings
- Antineoplastic Agents
- Brain Neoplasms
- Breast Neoplasms
- Carcinoma
- Drug Delivery Systems