Degeneration and repair in central nervous system disease.
review · Level V
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- Record sourced from PubMed, PMID 21052074.
- Also identified by DOI 10.1038/nm.2226 and PMC identifier 3985732.
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Abstract
Divergent disease triggers in neurodegeneration may induce convergent endogenous pathways in neuronal, glial and vascular elements as the central nervous system (CNS) attempts to compensate, remodel and recover. Dissecting these multicellular mechanisms and the integrative responses in cerebral blood flow and metabolism may allow us to understand the balance between injury and repair, validate new targets and define therapeutic time windows for neurodegeneration.
Medical subject headings
- Central Nervous System Diseases
- Nerve Degeneration
- Wound Healing