The evolution of rhPDGF-BB in musculoskeletal repair and its role in foot and ankle fusion surgery.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 21056861.
- Also identified by DOI 10.1016/j.fcl.2010.07.001.
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Abstract
Platelet-derived growth factor (PDGF) is one of the most thoroughly studied proteins in the body. Research has progressively highlighted the role of PDGF during wound healing and in the bone repair cascade. This research has resulted in FDA approval of 2 products containing a recombinant version of the protein, rhPDGF-BB, for treating chronic diabetic foot ulcers and periodontal bone defects. This article reviews the applicable basic science and mechanisms of action of PDGF, with attention to the increasingly defined role of rhPDGF-BB in initiating bone regeneration. The most recent data from prospective clinical trials evaluating the use of rhPDGF-BB in combination with beta tricalcium phosphate as a substitute for autogenous bone graft in hindfoot and ankle arthrodesis are also summarized.
Medical subject headings
- Ankle
- Arthrodesis
- Foot
- Orthopedic Procedures
- Platelet-Derived Growth Factor
- Recombinant Proteins
Anatomy
- ankle
- foot