Crystal structures of proline-derived enamines.
basic_science · Level V
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- Record sourced from PubMed, PMID 21068369.
- Also identified by DOI 10.1073/pnas.1006509107 and PMC identifier 2996454.
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Abstract
The isolation and structural characterization of both aldehyde- and ketone-derived proline enaminones are reported and discussed. Crystal structures of 10 proline enamines provide information on stereochemical aspects, i.e., double bond configuration and syn- vs. anti-positioning of the carboxylate relative to the enamine double bond. Furthermore, the obtained crystal structures are compared with the density functional theory-calculated structures of the ground and transition state and the postulated Seebach-Eschenmoser transition state.
Medical subject headings
- Proline