A dual-emission Förster resonance energy transfer nanoprobe for sensing/imaging pH changes in the biological environment.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 21082810.
- Also identified by DOI 10.1021/nn102644u.
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Abstract
A dual-emission nanoprobe that can sense changes in the environmental pH is designed based on the concept of pH-responsive Förster resonance energy transfer induced by the conformational transition of an associating polyelectrolyte, N-palmitoyl chitosan, bearing a donor (Cy3) or an acceptor (Cy5) moiety. We demonstrate that the developed pH-responsive nanoprobe can be used to ratiometrically image and thus discriminate the pH changes in the biological environment at different length scales.
Medical subject headings
- Fluorescence Resonance Energy Transfer
- Fluorescent Dyes
- Molecular Imaging
- Nanostructures