The role of leucine-rich repeat kinase 2 (LRRK2) in Parkinson's disease.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 21088684.
- Also identified by DOI 10.1038/nrn2935 and PMC identifier 4662256.
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Abstract
Parkinson's disease, like many common age-related conditions, is now recognized to have a substantial genetic component. Here, I discuss how mutations in a large complex gene--leucine-rich repeat kinase 2 (LRRK2)--affect protein function, and I review recent evidence that LRRK2 mutations affect pathways that involve other proteins that have been implicated in Parkinson's disease, specifically α-synuclein and tau. These concepts can be used to understand disease processes and to develop therapeutic opportunities for the treatment of Parkinson's disease.
Medical subject headings
- Genetic Predisposition to Disease
- Mutation
- Parkinson Disease
- Protein Serine-Threonine Kinases