Concise review: stem cells as an emerging platform for antibody therapy of cancer.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 21089119.
- Also identified by DOI 10.1002/stem.513 and PMC identifier 3003900.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
Monoclonal antibodies are important tools for cancer therapy, however, three factors limit their effectiveness: toxicity, poor tumor penetration, and inability to cross the blood-brain barrier. This review discusses the emerging field of stem cell-mediated antibody delivery and how this approach may improve antibody therapy of cancer by overcoming these obstacles.
Medical subject headings
- Antibodies
- Neoplasms
- Stem Cells