Melanoma cells express ICOS ligand to promote the activation and expansion of T-regulatory cells.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 21098714.
- Also identified by DOI 10.1158/0008-5472.CAN-10-1379 and PMC identifier 3058814.
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Abstract
CD4(+)CD25(+)Foxp3(+) T-regulatory cells (Tregs) accumulate in tumors; however, little is known about how the tumor environment influences this process. Here we show that human melanomas express inducible T-cell costimulator ligand (ICOS-L/B7H) that can provide costimulation through ICOS for the expansion of activated Tregs maintaining high Foxp3 and CD25 expression as well as a suppressive function. Thus, ICOS-L expression by melanoma tumor cells may directly drive Treg activation and expansion in the tumor microenvironment as another mechanism of immune evasion.
Medical subject headings
- Antigens, CD
- Cell Proliferation
- Melanoma
- T-Lymphocytes, Regulatory