Integral role of integrins in Th17 development.
Level V
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- Record sourced from PubMed, PMID 21099101.
- Also identified by DOI 10.1172/JCI45450 and PMC identifier 2993609.
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Abstract
A lineage of CD4+ T cells known as Th17 cells, which are derived by exposure of naive CD4+ T cells to IL-6 and TGF-β, have been implicated in several autoimmune diseases. In this issue of the JCI, studies by Acharya et al. and Melton et al. show that TGF-β is activated at the DC/CD4+ T cell synapse by αv integrins and that this activation is required for Th17 differentiation and autoimmunity in the central nervous system. Thus, these studies offer a potential therapeutic target in fighting autoimmune diseases.
Medical subject headings
- Integrins
- Th17 Cells