Bone formation on carbon nanotube composite.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 21105154.
- Also identified by DOI 10.1002/jbm.a.32958.
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Abstract
The effects of a layer-by-layer assembled carbon nanotube composite (CNT-comp) on osteoblasts in vitro and bone tissue in vivo in rats were studied. The effects of CNT-comp on osteoblasts were compared against the effects by commercially pure titanium (cpTi) and tissue culture dishes. Cell proliferation on the CNT-comp and cpTi were similar. However, cell differentiation, measured by alkaline phosphatase activity and matrix mineralization, was better on the CNT-comp. When implanted in critical-sized rat calvarial defect, the CNT-comp permitted bone formation and bone repair without signs of rejection or inflammation. These data indicate that CNT-comp may be a promising substrate for use as a bone implant or as a scaffold for tissue engineering.
Medical subject headings
- Nanotubes, Carbon
- Osteoblasts
- Osteogenesis