Lab-in-a-tube: detection of individual mouse cells for analysis in flexible split-wall microtube resonator sensors.
basic_science · Level V
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- Record sourced from PubMed, PMID 21105718.
- Also identified by DOI 10.1021/nl1036148.
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Abstract
We report a method for the precise capturing of embryonic fibroblast mouse cells into rolled-up microtube resonators. The microtubes contain a nanometer-sized gap in their wall which defines a new type of optofluidic sensor, i.e., a flexible split-wall microtube resonator sensor, employed as a label-free fully integrative detection tool for individual cells. The sensor action works through peak sharpening and spectral shifts of whispering gallery modes within the microresonators under light illumination.