Wnt signaling and aging-related heart disorders.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 21106946.
- Also identified by DOI 10.1161/CIRCRESAHA.110.223776.
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Abstract
Aging is associated with various heart diseases, and this may be attributable, in part, to the prolonged exposure of the heart to cardiovascular risk factors. However, aging is also associated with heart disorders such as diastolic dysfunction that are not necessarily linked to the risk factors for cardiovascular diseases. Recent studies have demonstrated a mechanistic link between Wnt signaling and premature aging or aging-related phenotypes. As a part of the review series on Wnt signaling and the cardiovascular system, we discuss here the possible involvement of Wnt signaling in aging-associated heart diseases or heart disorders.
Medical subject headings
- Aging
- Heart Diseases
- Signal Transduction
- Wnt Proteins