Lipotoxicity and the development of heart failure: moving from mouse to man.
basic_science · Level V
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- Record sourced from PubMed, PMID 21109186.
- Also identified by DOI 10.1016/j.cmet.2010.11.016 and PMC identifier 3330240.
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Abstract
Intracardiac lipid accumulation can cause heart failure. A study in Journal of Clinical Investigation (Son et al., 2010) found that cardiac-specific PPARγ overexpression caused heart failure with intracardiac triglyceride accumulation. Overexpressing PPARγ on a PPARα-/- background improved cardiac function, suggesting that specific lipid metabolites and lipid packaging determine cardiac lipotoxicity.