Stressed-out mitochondria get MAD.
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- Record sourced from PubMed, PMID 21109188.
- Also identified by DOI 10.1016/j.cmet.2010.11.018 and PMC identifier 3018381.
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Abstract
Mechanisms maintaining mitochondrial integrity range from specific repair pathways to wholesale degradation of damaged organelles. A recent study in Molecular Cell (Heo et al., 2010) adds another mechanism to this mitochondrial homeostasis toolkit: mitochondria-associated protein degradation (MAD) that ultimately directs endoplasmic reticulum-associated protein degradation (ERAD) pathway components to oxidatively stressed mitochondria.