Evaluating antirheumatic treatments using synovial biopsy: a recommendation for standardisation to be used in clinical trials.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 21109518.
- Also identified by DOI 10.1136/ard.2010.139550.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
Inflammation of synovium is one of the hallmarks of rheumatoid arthritis (RA). Analysis of synovial tissue has increased our understanding of RA pathogenesis, aided in identifying potential therapeutic targets and has been used in the response and mechanistic evaluation of antirheumatic treatments. In addition, studies are ongoing, aimed at the identification of diagnostic and prognostic biomarkers in the synovium. This paper outlines the currently used procedures for sampling and processing of synovial tissue, and presents a standardised recommendation to support multicentre translational research.
Medical subject headings
- Antirheumatic Agents
- Arthritis, Rheumatoid
- Biopsy
- Synovial Membrane
- Synovitis