ATP consumption promotes cancer metabolism.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 21111226.
- Also identified by DOI 10.1016/j.cell.2010.11.010.
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Abstract
Cancer cells metabolize glucose by aerobic glycolysis, a phenomenon known as the Warburg effect. Fang et al. (2010) show that the endoplasmic reticulum enzyme ENTPD5 promotes ATP consumption and favors aerobic glycolysis. The findings suggest that nutrient uptake in cancer cells is limited by ATP and satisfies energy requirements other than ATP production.