Accelerometry and its association with objective markers of walking limitations in ambulatory adults with multiple sclerosis.

Abstract

To validate accelerometry based on its correlations with 6-minute walk distance (6MWD) and oxygen cost of walking as objective markers of walking limitations in multiple sclerosis (MS). Cross-sectional. Laboratory and general community. Ambulatory participants with MS (N=26) who resided in the local community. Not applicable. Patient Determined Disease Steps (PDDS) scale and Multiple Sclerosis Walking Scale-12 (MSWS-12); 6-minute walk test while wearing a portable metabolic unit for measuring the 6MWD and oxygen cost of walking; accelerometer during the waking hours of a 7-day period. The average of total daily movement counts from the accelerometer correlated significantly and strongly with MSWS-12 scores (ρ=-.681, P=.001), PDDS scores (ρ=-.609, P=.001), 6MWD (ρ=.519, P=.003), and oxygen cost of walking (ρ=-.541, P=.002). We provide evidence that further supports the validity of accelerometry as a measure of walking limitations in ambulatory persons with MS.