What makes plaques vulnerable in CKD?: a fresh look at metalloproteinases.
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 21116271.
- Also identified by DOI 10.1038/ki.2010.366.
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Abstract
Coll et al. show that across the spectrum of chronic kidney disease (CKD), atherosclerosis severity is correlated with metalloproteinase-10 (MMP-10) levels. This suggests that the reduced fibrous content in atherosclerotic plaques may result partly from high MMP-10. Future studies should look at the association of MMPs (and their inhibitors) with the inflammatory component of atherosclerosis, and with stable and unstable atherosclerotic lesions.
Medical subject headings
- Kidney Diseases
- Matrix Metalloproteinase 10
- Plaque, Atherosclerotic