Genetics: Rare genes for autoimmunity-the new kids on the block.

Abstract

Genome-wide association studies of human diseases have uncovered large numbers of common genetic variants with low effect sizes; however, rare genetic variants with large effect sizes may have greater relevance with respect to disease heritability. The identification and characterization of rare variants such as <i>SIAE</i> is, therefore, likely to be a major endeavor in the field in the coming years.