JULIDE: a software tool for 3D reconstruction and statistical analysis of autoradiographic mouse brain sections.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 21124830.
- Also identified by DOI 10.1371/journal.pone.0014094 and PMC identifier 2991313.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
In this article we introduce JULIDE, a software toolkit developed to perform the 3D reconstruction, intensity normalization, volume standardization by 3D image registration and voxel-wise statistical analysis of autoradiographs of mouse brain sections. This software tool has been developed in the open-source ITK software framework and is freely available under a GPL license. The article presents the complete image processing chain from raw data acquisition to 3D statistical group analysis. Results of the group comparison in the context of a study on spatial learning are shown as an illustration of the data that can be obtained with this tool.
Medical subject headings
- Brain
- Image Processing, Computer-Assisted
- Imaging, Three-Dimensional
- Software